Two switches: the clock and the pressure
You will be able to: Explain why you are sleepy at night and alert in the day, using the body clock and sleep pressure.
Most of us think of sleepiness as one feeling. Sleep scientists describe it as the result of two processes working together. Once you can picture them, a lot of everyday puzzles make sense: the "second wind" late in the evening, the dip after lunch, and the coffee that "stops working".
Switch 1: the body clock
Deep in your brain, in an area called the hypothalamus, sits a large group of nerve cells called the suprachiasmatic nucleus, or SCN for short. It is your master clock. It gets information about light straight from your eyes, and it keeps the other clocks in your body in step. Alertness, body temperature, metabolism and the release of hormones all rise and fall on a daily cycle.
These daily cycles are called circadian rhythms. They run on a cycle of about 24 hours, and light and dark have the biggest influence on them. Left completely on its own, without daylight or clocks, the human clock runs a little longer than 24 hours on average, so it needs a small daily nudge to stay matched to the real day. That nudge is the subject of the next unit.
What does the clock do for sleep? It helps make you sleepy at night and helps you wake in the morning. It also seems to push hardest for wakefulness in the evening, just when sleep pressure is building up: studies of sleep timing found a window of a few hours before the usual bedtime when people rarely fall asleep, and a smaller dip in alertness in the mid-afternoon. That is why many people get a "second wind" in the evening if they stay up, and why the early afternoon can feel heavy.
Switch 2: sleep pressure
The second process is simpler. From the moment you wake up, a drive to sleep starts to build. It gets stronger every hour you are awake, and after a long time without sleep you sleep longer and more deeply. Sleep releases it again, a bit like a bath that slowly fills during the day and drains overnight.
One of the substances linked to this pressure is adenosine, a chemical released by cells that helps make you feel sleepy. In animal studies, its levels in part of the brain rose the longer the animals stayed awake and fell again during sleep. Keep that word in mind: it is exactly what caffeine interferes with (unit 4).
How the two work together
Picture the two signals across one day:
In the evening, the pressure is high but the clock is still pushing back, so you can stay awake. Then the clock's signal falls away, and sleep comes easily. By the morning, the pressure has drained and the clock helps you wake.
This idea is known in sleep science as the two-process model. It was first set out in 1982 and, with updates over the years, it is still a major framework in sleep research.
Try it: are you sharper in the morning or the evening?
You met the 1-minute alertness test in Module 1. The two switches suggest that your results may change across the day. Do one run now. Over the next few days, add a run soon after getting up and one late in the evening, on the same device. Press "Compare my runs" to see them side by side by time of day.
A few runs on a few days tell you far more than one. Expect some noise: a single slow run means little.
Quick check (3 questions)
Sources
- NIGMS (NIH), Circadian rhythms (the master clock, the SCN, light and dark as the biggest influence)
- NINDS, Brain basics: understanding sleep (the SCN in the hypothalamus; the circadian rhythm and the sleep drive working together; adenosine and caffeine)
- Porkka-Heiskanen et al. (1997), Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness, Science 276(5316): 1265-8, PubMed 9157887 (the animal study)
- Strogatz, Kronauer & Czeisler (1987), Am J Physiol 253(1): R172-8, PubMed 3605382; Lavie (1986), Electroencephalogr Clin Neurophysiol 63(5): 414-25, PubMed 2420557 (the evening window and the afternoon dip)
- Borbély (1982), A two process model of sleep regulation, Human Neurobiology 1(3): 195-204, PubMed 7185792; Borbély et al. (2016), J Sleep Res 25(2): 131-43, PubMed 26762182
- Czeisler et al. (1999), Science 284(5423): 2177-81, PubMed 10381883
- NHS, Insomnia (do not nap during the day)
- Basner & Dinges (2011), Sleep 34(5): 581-91, PubMed 21532951 (the reaction test)
Next: light, the daily reset button